Characterization of the Catalase Gene in Aspergillus salvadorensis 1 and its Role in Oxidative Stress
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Date
2026-06-04
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International Journal of Nanotechnology and Allied Sciences
Abstract
In this study, a genomic sequence of approximately 1,980 base pairs obtained by nextgeneration Illumina sequencing was analyzed of the Aspergillus salvadorensis, with
the aim of identifying functional elements associated with the adaptation of the
organism. The bioinformatic analysis allowed the detection of an open reading
framework whose conceptual translation evidenced high homology with enzymes of
the catalase family. The presence of conserved domains and key residues associated
with the active site confirmed its role in hydrogen peroxide detoxification. These
results are integrated with the relevance of uridine monophosphate biosynthesis and
epigenetic regulation, essential processes for growth and stress response. Taken
together, it is proposed that the interaction between these systems confers a significant
adaptive advantage on Aspergillus salvadorensis in its natural environment. Catalase
acts as a shield against the immune system. The catalase produced by the fungus acts
as a critical defense mechanism by neutralizing reactive oxygen species, allowing it to
survive the host's immune system and facilitating the progression of the infection. In
this process, the catalase gene, specifically the catA type, is prominently expressed in
the conidia to protect the spore during its dormant state and ensure its resistance to
adverse environmental factors such as heat, desiccation, and ultraviolet radiation.
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Keywords
Aspergillus salvadorensis, Catalase, Oxidative Stress, Uridine Monophosphate, Epigenetics, Bioinformatics