Characterization of the Catalase Gene in Aspergillus salvadorensis 1 and its Role in Oxidative Stress

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dc.contributor.authorVàsquez Hidalgo, Antonio
dc.contributor.otherantonio.vasquez@ues.edu.sv
dc.date.accessioned2026-06-05T14:03:46Z
dc.date.available2026-06-05T14:03:46Z
dc.date.issued2026-06-04
dc.description.abstractIn this study, a genomic sequence of approximately 1,980 base pairs obtained by nextgeneration Illumina sequencing was analyzed of the Aspergillus salvadorensis, with the aim of identifying functional elements associated with the adaptation of the organism. The bioinformatic analysis allowed the detection of an open reading framework whose conceptual translation evidenced high homology with enzymes of the catalase family. The presence of conserved domains and key residues associated with the active site confirmed its role in hydrogen peroxide detoxification. These results are integrated with the relevance of uridine monophosphate biosynthesis and epigenetic regulation, essential processes for growth and stress response. Taken together, it is proposed that the interaction between these systems confers a significant adaptive advantage on Aspergillus salvadorensis in its natural environment. Catalase acts as a shield against the immune system. The catalase produced by the fungus acts as a critical defense mechanism by neutralizing reactive oxygen species, allowing it to survive the host's immune system and facilitating the progression of the infection. In this process, the catalase gene, specifically the catA type, is prominently expressed in the conidia to protect the spore during its dormant state and ensure its resistance to adverse environmental factors such as heat, desiccation, and ultraviolet radiation.
dc.identifier.issnISSN: 3107-5509 (Online)
dc.identifier.urihttps://hdl.handle.net/20.500.14492/33559
dc.language.isoen
dc.publisherInternational Journal of Nanotechnology and Allied Sciences
dc.relation.ispartofseriesVolume-2, Issue-3 (May-June) 2026 ; https://ikrpublishers.com/wp-content/uploads/2026/05/IKRJAB55339-2026.pdf
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectAspergillus salvadorensis
dc.subjectCatalase
dc.subjectOxidative Stress
dc.subjectUridine Monophosphate
dc.subjectEpigenetics
dc.subjectBioinformatics
dc.titleCharacterization of the Catalase Gene in Aspergillus salvadorensis 1 and its Role in Oxidative Stress
dc.typeTrabajo de grado

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